Installation Conditions for Refrigeration Systems with Different Refrigerants
Refrigerant and room volume - a safety comparison
11/10/2025
Refrigeration systems are essential components in many industrial and commercial applications that are used for cooling or general temperature control of processes, reactors or test specimens. When planning and installing such systems, choosing the right installation location plays a crucial role. Different refrigerants have different physical and chemical properties that influence the safety and efficiency of the system. A key aspect here is taking into account the room volume requirements in order to minimize risks in the event of a leak.
Safety requirements for leaks
One of the most important safety considerations when operating refrigeration systems is the potential risk of a leak in the refrigeration circuit. If refrigerant leaks, it can mix with the air in the room, depending on its chemical composition and the ambient conditions. Some refrigerants can form flammable mixtures in certain concentrations. To actively prevent this, a certain room volume must be available, depending on the refrigeration system, if there is no active ventilation in the installation location.
Special features when installing multiple refrigeration systems
It often happens that several refrigeration systems are installed in one room. What room volume requirements must then be observed?
For this question, it is crucial that each system is assessed individually. Even if there are several refrigeration systems in a room, it is unlikely that several leaks will occur simultaneously and in a causally connected manner. Therefore, the room volume requirement does not increase if several units are placed in one room.
Room volume requirements for different refrigerants
The calculation of the required room size for the installation of a refrigeration system is based on the specific density and the safety-related properties of the refrigerant used. Here are some examples:
| Refrigerant | Properties | Required room volume per kg |
| R290 (propane) | combustible | 125 m³ |
| R1270 (propene) | combustible | 125 m³ |
| R449A | lowly flammable/toxic | 2,8 m³ |
| R452A | lowly flammable/toxic | 2.4 m³ |
Conclusion
The correct selection of the installation location for refrigeration systems is of central importance for the operational safety and efficiency of the systems. In particular, the requirements for the room volume that must be available per kilogram of refrigerant must not be neglected.
At JULABO, the refrigerant used and the respective quantity are always specified on the nameplate of the appliance.
Our experienced temperature control experts will be happy to answer any questions you may have about installation conditions or calculating the required cubage.